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Managed Care Law Weekly

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University of Amsterdam



Brugada syndrome is not fully explained by one single mechanism



October 9th, 2005

A recent report focused on the pathophysiological mechanisms of Brugada syndrome.

According to the report from the Netherlands, "After its recognition as a distinct clinical entity, Brugada syndrome is increasingly recognized worldwide as an important cause of sudden cardiac death. Brugada syndrome exhibits autosomal dominant inheritance with SCN5A, which encodes the cardiac sodium channel, as the only gene with a proven involvement in 20-30% of patients. Its signature feature is ST segment elevation in right precordial ECG leads and predisposition to malignant ventricular tachyarrhythmias."

P.G. Meregalli and colleagues of the University...


Source: Managed Care Law Weekly (2005-10-09)

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