Published in Managed Care Law Weekly, January 22nd, 2006
"DIM type 1 is associated with an expansion of (>50) CTG repeats within the 3' untranslated region (UTR) of the dstrophin myotonin protein kinase gene (dmpk). In the corresponding mRNA transcript, the CUG repeats form an extended stem-loop structure."
B.H. Mooers and colleagues of the University of Oregon, wrote, "The double-stranded RNA of the stem sequesters RNA binding proteins away from their normal cellular targets resulting in aberrant transcription, alternative splicing patterns, or both, thereby leading...
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