De Montfort University, UK
Investigators at De Montfort University target cancer
Published in Managed Care Law Weekly, November 12th, 2006
A report, "Inhibition of cancer cell growth by cyclin dependent kinase 4 inhibitors synthesized based on the structure of fascaplysin," is newly published data in Bioorganic Chemistry. "Tryptamine derivatives, a new structural class of cyclin dependent kinase 4 inhibitors, have been identified during extensive biological screening of synthetic molecules. The molecules were synthesized based on the structure of fascaplysin, which is not only a specific inhibitor of the Cdk4-cyclin D1 enzyme but also a relatively toxic molecule, probably because it binds and intercalates DNA," scientists writing in the journal Bioorganic Chemistry report.
"Interestingly, the new...
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