M.D. Anderson Cancer Center

PI3-K pathway may be major pathway for trastuzumab-mediated radiosensitization

Published in Medical Device Business Week, January 12th, 2004

Researchers say the PI3-K pathway might be the major pathway for trastuzumab-mediated radiosensitization of breast cancer cells.

According to published research from the United States, "HER2, a member of the human epidermal growth factor (EGF) receptor family, not only plays important roles in the progression of breast cancer tumorigenesis and metastasis, but may protect cancer cells from conventional cytotoxic therapies as well.

"In the current study, we evaluated the effect of targeting HER2 on radiosensitization of human breast cancer cells. Using six breast cancer cell lines with various levels of HER2 (BT474, SKBR3, MDA453, MCF7, ZR75B, and...

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Source: Medical Device Business Week (2004-01-12)

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