Center of Oncology, Poland
Ku86 levels correlate with magnitude of radiation-induced lymphocyte DNA breaks
Published in Medical Device Business Week, April 28th, 2004
"The Ku heterodimer, which consists of Ku70 and Ku86 subunits, is a major sensor of DNA breaks," wrote researchers in Poland.
"A truncated form of Ku86 lacking its C-terminus, termed Ku86 variant, has been detected in extracts from different human cells. In "human lymphocytes the Ku86 variant is not present in vivo but is generated in vitro upon cell lysis by a trypsin-like protease. The resulting Ku86 variant exists exclusively in complexes with Ku70, which possess strong affinity to DNA double strand termini," reported J. Lanuszewska and...
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