Proteomics
Research conducted at Chiba University, Department of Molecular has provided new information about proteomics
Published in Medical Device Business Week, January 24th, 2007
New research, "Two distinct cytotoxic activities of subtilase cytotoxin produced by shiga-toxigenic Escherichia coli," is the subject of a report. According to recent research from Chiba, Japan, "Subtilase cytotoxin (SubAB) is a recently identified AB5 subunit toxin produced by Shiga-toxigenic Escherichia coli. The A subunit is thought to be a subtilase-like, serine protease, whereas the B subunit binds to the toxin receptor on the cell surface."
"We cloned the genes from a clinical isolate; the toxin was produced as His-tagged proteins. SubAB induced vacuolation at concentrations greater than 1 microg/ml after 8 h, in addition to the reported cytotoxicity...
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