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Alzheimer Disease

Howard Hughes Medical Institute scientists discover new genetic risk factor for Alzheimer

Published in Medical Device Business Week, February 14th, 2007

Researchers, led by Howard Hughes Medical Institute (HHMI) international research scholar Peter St George-Hyslop, have identified a new genetic risk factor associated with the most common form of Alzheimer disease.

The research implicates a gene called SORL1 in late-onset Alzheimer disease, which usually strikes after age 65.

In an advance online publication in Nature Genetics, St George-Hyslop and colleagues connected the gene to the disease in six different groups of people, although they did not pinpoint the exact genetic mutations in SORL1 responsible for Alzheimer.

In their studies, the researchers used databases that...

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