Breast Cancer Prognosis
New breast cancer prognosis data have been reported by scientists at Erasmus Medical Center, Department of Medical Oncology
Published in Medical Device Business Week, September 5th, 2007
New research, "Concentrations of TIMP1 mRNA splice variants and TIMP-1 protein are differentially associated with prognosis in primary breast cancer," is the subject of a report. According to a study from Rotterdam, Netherlands, "TIMP-1 protein is a prognostic factor for recurrence-free and overall survival (OS) time in breast cancer. We evaluated the prognostic value of TIMP1 mRNA and a novel TIMP1 mRNA splice variant in 1301 primary breast cancer patients."
"We measured mRNA transcripts of full-length TIMP1 (TIMP1-v1) and the novel splice variant lacking exon 2 (TIMP1-v2) by use of real-time RT-PCR in frozen primary tumor samples. Transcript concentrations are...
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