Von Willebrand Disease

New findings reported from J.C. Gilbert and co-authors describe advances in von Willebrand disease

Published in Medical Device Business Week, February 6th, 2008

According to recent research from the United States, "ARC1779 is a therapeutic aptamer antagonist of the A1 domain of von Willebrand Factor (vWF), the ligand for receptor glycoprotein 1b on platelets. ARC1779 is being developed as a novel antithrombotic agent for use in patients with acute coronary syndromes."

"This was a randomized, double-blind, placebo-controlled study in 47 healthy volunteers of doses of ARC1779 from 0.05 to 1.0 mg/kg. Pharmacodynamic effects were measured by an ELISA for free vWF A1 binding sites and by a platelet function analyzer. In terms of pharmacokinetics, the concentration-time profile of ARC1779 appeared monophasic. The observed...

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Source: Medical Device Business Week (2008-02-06)

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