Leukemia

Scientists at Children's Hospital report research in leukemia

Published in Medical Device Business Week, April 16th, 2008

"The ETV6 gene has been reported to be fused to a multitude of partner genes in various hematologic malignancies with 12p13 aberrations. Cytogenetic analysis of six cases of childhood acute lymphoblastic leukemia revealed a novel recurrent t(8;12) (q13;p13), suggesting involvement of ETV6," scientists in Vienna, Austria report.

"Fluorescence in situ hybridization was used to confirm the involvement of ETV6 in the t(8;12)(q13;p13) and reverse transcription-PCR was used to identify the ETV6 partner gene. Detailed immunologic characterization was done, and owing to their lineage promiscuity, the leukemic blast cells were analyzed for NOTCH1 mutations. We have identified a...

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Source: Medical Device Business Week (2008-04-16)

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