Pharmacokinetics
Research from Shandong University provide new insights into pharmacokinetics
Published in Medical Device Business Week, June 18th, 2008
In this recently published article, scientists in Jinan, People's Republic of China conducted a study "To develop a high performance liquid chromatography mass spectrometry (HPLC-MS) method for the determination of the glycyrrhetic acid (GA) in human plasma and for the investigation of its pharmacokinetics after the oral administration of 150 mg diammonium glycyrrhizinate test and reference capsule formulations. The GA in plasma was extracted with ethyl acetate, separated on a C-18 column with a mobile phase of methanol (5 mmol/L ammonium acetate)-water (85:15, V/V) and analysed using a MS detector."
"Ursolic acid (UA) was used as internal standard. The target ions...
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