Published in Medical Device Business Week, December 17th, 2008
"This subset expresses CD11c and produces high levels of proinflammatory cytokines that are linked to the development of obesity-associated insulin resistance. Here, we used a conditional cell ablation system, based on transgenic expression of the diphtheria toxin receptor under the control of the CD11c promoter, to study the effects of depletion of CD11c(+) cells in obese mouse models. Our results show that CD11c(+) cell depletion results in...
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