Bioengineering

New research on bioengineering from University of California summarized

Published in Medical Device Business Week, January 14th, 2009

"At the neuromuscular junction, the acetylcholine receptor (AChR) is specifically clustered in the postsynaptic membrane via interactions with rapsyn and other scaffolding proteins. However, it remains unclear where these proteins bind on the AChR and how the interactions are regulated," scientists writing in the Journal of Neuroscience report.

"Here, we define a phosphorylation-dependent binding site on the receptor that mediates agrin-induced clustering. Using chimeric proteins in which CD4 is fused to the large intracellular loop of each of the AChR subunits we found that agrin induced clustering of only chimeras containing the beta subunit loop. By making...

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Source: Medical Device Business Week (2009-01-14)

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