Cardiology

Research on cardiology discussed by scientists at University of Bristol

Published in Medical Device Business Week, February 4th, 2009

According to a study from Bristol, the United Kingdom, "Spontaneous Ca2+ release from the sarcoplasmic reticulum (SR) appears to play an important role in cardiac sinoatrial node pacemaking. However, comparatively little is known about the role of intracellular Ca2+ in the atrioventricular node (AVN)."

"Intracellular Ca2+ was therefore monitored in cells isolated from the rabbit AVN, using fluo-3 in conjunction with confocal microscopy. These cells displayed spontaneous Ca2+ transients and action potentials. Ca2+ transients were normally preceded by a small, slow increase (ramp) of intracellular Ca2+ which was sometimes, but not always, accompanied by Ca2+ sparks....

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Source: Medical Device Business Week (2009-02-04)

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