Immunofluorescence

Data from Rockefeller University advance knowledge in immunofluorescence

Published in Medical Device Business Week, February 11th, 2009

According to recent research from the United States, "Cell wall peptidoglycan-anchored surface proteins are essential virulence factors in many gram-positive bacteria. The attachment of these proteins to the peptidoglycan is achieved through a transpeptidation reaction, whereby sortase cleaves a conserved C-terminal LPXTG motif and covalently attaches the protein to the peptidoglycan precursor lipid If."

"It is unclear how the sorting reaction is regulated spatially and what part sortase localization plays in determining the distribution of surface proteins. This is mainly the result of inadequate immunofluorescence techniques required to resolve these issues in certain...

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Source: Medical Device Business Week (2009-02-11)

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