Cancer

Studies from Hadassah University describe new findings in cancer

Published in Medical Device Business Week, April 22nd, 2009

"Inhibition of epidermal growth factor receptor tyrosine kinase (EGFR-TK) has emerged as a major approach for cancer-targeted therapy. Consequently, there has been a great interest in the use of labeled EGFR-TK inhibitors as positron emission tomography (PET) imaging agents," researchers in Jerusalem, Israel report.

"Currently, the developed agents did not yield adequate PET imaging of animal models probably due to poor solubility, rapid washout from blood, and low stability in vivo. In order to overcome these hurdles, new derivatives of previously reported inhibitors (ML04, 2) with decreased log P and increased solubility were designed and synthesized. These compounds...

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Source: Medical Device Business Week (2009-04-22)

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