Electron Microscopy
Research reports from R. Tycko and co-authors provide new insights into electron microscopy
Published in Medical Device Business Week, September 9th, 2009
"Asp23-to-Asn mutation within the coding sequence of beta-amyloid, called the Iowa mutation, is associated with early onset, familial Alzheimer's disease and cerebral amyloid angiopathy, in which patients develop neuritic plaques and massive vascular deposition predominantly of the mutant peptide. We examined the mutant peptide, D23N-A beta 40, by electron microscopy, X-ray diffraction, and solid-state NMR spectroscopy," scientists in the United States report.
"D23N-A beta 40 forms Fibrils considerably faster than the wild-type peptide (k = 3.77 x 10(-3) min(-1) and 1.07 x 10(-4) min(-1) for D23N-A beta 40 and the wild-type peptide WT-A beta 40, respectively) and...
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