Life Sciences

Studies from GlaxoSmithKline, Collegeville describe new findings in life sciences

Published in Medical Device Business Week, September 9th, 2009

According to a study from the United States, "Functional screening of the former SmithKline Beecham compound collection against the human calcium receptor (CaR) resulted in the identification of the amino alcohol-based hit 2 (IC50 = 11 mc M)Structure-activity Studies of 2 focused on the optimization of the right- and left-hand side aromatic moieties as well as the amino alcohol linker region."

"Critical to the optimization of this antagonist template was the discovery that the chirality of the C-2 secondary alcohol played a key role in enhancing both CaR potency as well as selectivity over the beta-adrenergic receptor subtypes. These SAR studies ultimately led to the...

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Source: Medical Device Business Week (2009-09-09)

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