Behavior

Studies from Oregon State University update current data on behavior

Published in Medical Device Business Week, November 4th, 2009

"The air-water surface tension kinetic and steady state behavior exhibited by a recombinant Factor VIII were recorded in the presence of the surfactant Tween 80. The rate of surface tension decrease was determined to be greater for rFVIII-Tween mixtures than for Tween acting alone, at all Tween concentrations studied (8-108 ppm)," scientists writing in the Journal of Pharmaceutical Sciences report.

"In addition, steady state interfacial behavior was determined to be governed entirely by surfactant adsorption in mixtures with Tween concentrations greater than or equal to about 18 ppm. The formation of aggregates, tertiary structure change, and biological activity...

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Source: Medical Device Business Week (2009-11-04)

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