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Beth Israel Deaconess Medical Center, Boston, U.S.

Eptifibatide during percutaneous coronary stenting is feasible and safe

Published in Medical Device Law Weekly, August 27th, 2006

Intracoronary (IC) bolus administration of eptifibatide is feasible and safe among patients with unstable angina/non ST elevation myocardial infarction (UA/NSTEMI).

According to recent research from the United States, "Distal embolization of thrombotic debris may occur during and after percutaneous coronary intervention (PCI) for acute coronary syndromes. This may lead to impaired microvascular perfusion, myocardial infarction and increased morbidity and mortality. In vitro studies suggest that high local concentrations of a glycoprotein IIb/IIIa inhibitor may be effective in disaggregating thrombus and thereby prevent microvascular compromise. We hypothesized that IC...

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