Proteomics

Reports outline proteomics study findings from P.A. Raj and colleagues

Published in Medical Device Law Weekly, May 11th, 2008

"New molecules were designed for efficient intra-oral delivery of antimicrobials to prevent and treat oral infection. The salivary statherin fragment, which has high affinity for the tooth enamel, was used as a carrier peptide," scientists in the United States report.

"This was linked through the side chain of the N-terminal residue to the C-terminus of a defensin-like 12-residue peptide to generate two bifunctional hybrid molecules, one with an ester linkage and the other with an anhydride bond between the carrier and the antimicrobial components. They were examined for their affinity to a HAP (hydroxyapatite) surface. The extent of the antimicrobial release in human...

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Source: Medical Device Law Weekly (2008-05-11)

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