Microdialysis

Research from K. Mizoguchi et al broadens understanding of microdialysis

Published in Medical Device Law Weekly, October 26th, 2008

"We previously demonstrated that suppression of glucocorticoid secretion by adrenalectomy (ADX) impaired prefrontal cortex-sensitive working memory, but not reference memory. Since the cholinergic system in the hippocampus is also involved in these memories, we examined the effects of glucocorticoid suppression on cholinergic transmission in the rat hippocampus," scientists in Japan report.

"A microdialysis study revealed that ADX did not affect the basal acetylcholine release, but enhanced the KCl-evoked response. This enhanced response was reversed by the corticosterone replacement treatment. The extracellular choline concentrations increased under both basal and...

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Source: Medical Device Law Weekly (2008-10-26)

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