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Edema

New edema research from University of Oklahoma discussed

Published in Medical Device Law Weekly, December 28th, 2008

"Bacillus anthracis edema toxin (ET) generates high levels of cyclic AMP and impacts a complex network of signaling pathways in targeted cells. In the current study, we sought to identify kinase signaling pathways modulated by ET to better understand how this toxin alters cell physiology," researchers in the United States report.

"Using a panel of small-molecule inhibitors of mammalian kinases, we found that inhibitors of glycogen synthase kinase 3 beta (GSK-3 beta) protected cells from ET-induced changes in the cell cycle. GSK-3 beta inhibitors prevented declines in cellular levels of cyclin D1 and c-Jun following treatment of macrophages with ET. Strikingly, cell...

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