Pharmacokinetics
Reports on pharmacokinetics findings from Y.C. Ren and co-researchers provide new insights
Published in Medical Device Law Weekly, July 12th, 2009
According to recent research from Shenyang, People's Republic of China, "The aim of this study was to investigate the local pharmacokinetics and site-specific target efficiency of ambroxol hydrochloride (AH) dry powder inhalation (DPI) by comparing lung epithelial lining fluid (ELF) and plasma AH levels after tracheal administration (TA) with those after intravenous administration. Twelve rats were divided into two groups, one of which was given AH DPI (20 mg/kg) via the trachea and the other was given the same dose AH by intravenous injection (i.v.)."
"Afterwards, each group was subdivided into two groups. The concentration of AH in the ELF was determined by...
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