Acute Promyelocytic Leukemia
Real-time multiplex RT-PCR useful for t(15;17) analysis
Published in Medical Devices and Surgical Technology Week, March 9th, 2003
"Individuals with acute promyelocytic leukemia (APL) usually express one of three primary hybrid transcripts associated with a t(15;17)," explained P. C. Choppa and coauthors, IMPATH. "The three fusion transcripts are the result of heterogeneous breakpoint cluster regions (bcr) within the promyelocytic leukemia (PML) gene and are denoted bcr1 (long), bcr2 (variant), and bcr3 (short) forms."
"Many researchers have shown that real-time quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) of the involved transcript...
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