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Stem-Cell Transplantation

Gemtuzumab ozogamicin increases VOD risk in myeloablative stem cell graft recipients

Published in Medical Devices and Surgical Technology Week, October 19th, 2003

Gemtuzumab ozogamicin (GO) treatment increases the risk of VOD in myeloablative stem cell graft recipients

GO, "a monoclonal antibody used in the treatment of acute myelogenous leukemia (AML) has been linked to the development of veno-occlusive disease (VOD)," scientists in Boston noted.

To "determine whether GO exposure prior to allogeneic SC transplantation increases the risk of developing VOD," M. Wadleigh and coauthors at the Dana-Farber Cancer Institute "conducted a retrospective study of 62 patients with previously treated AML/MDS (myelodysplastic syndrome) who underwent allogeneic stem cell (SC) transplantation at our institution from December...

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