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Medical Devices and Surgical Technology Week

Susan Hasty, Publisher

Table of Contents . . . June 20th, 2004

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Medical Devices and Surgical Technology Week | Other Publications

Biotechnology - Encoded microcarriers enable simultaneous analysis of multiple cell types

Diagnostics - Novel method for measuring multiple cytokines from small samples

Diagnostics - Single-cell PCR useful for leptomeningeal B-cell cancer diagnosis

Drug Delivery - Thermal aerosol system enables rapid drug action

Food-Borne Illness - Rapid fluorimetric microplate assay detects seafood toxins

Proteomics - High-throughput assay measures tumor cell S-phase progression

Allergy Medicine - Optimal occlusion time determined for pediatric atopy patch test

Alveolar Soft-Part Sarcoma - Alveolar soft-part sarcoma responsive to intensive chemotherapy

Alzheimer Disease - Neuropathology assessed in mouse model of Alzheimer disease

Anesthesiology - Guidance system can reduce awareness during surgery

Angiology - Renin plus angiotensinogen in renal proximal tubule increases arterial pressure

Animal Models - Silicone balloon catheters facilitate study of visceral pain in animals

Anthrax - Exotoxin components of Bacillus anthracis analyzed by Western blot

Anthrax - Monoclonal antibodies to B. anthracis capsular antigen developed

Antibiotics - Antibiotic-loaded collagen-hyaluronic acid matrix potentially a skin substitute

Apoptosis - Hydrogen peroxide induces topoisomerase I-mediated DNA damage and cell death

Asthma - CysLT1 receptor expression induces airway responsiveness to leukotriene D-4

Asthma - No link between anti-pneumonia antibodies and asthma

Asthma Therapy - Benzalkonium-induced anaphylaxis reported in nebulizer user

Bacteriology - Protein of Treponema denticola inhibits binding step of collagen phagocytosis

Benign Prostatic Hyperplasia - Cooled ThermoCath catheter provides improved patient comfort in trial

Bioengineering - A novel genetically engineered marker keeps track of stem cells in vivo

Biohazards - Company unveils technology for collection of biohazardous materials

Biotechnology - FRET-based analysis detects subtle change in early cycle-related gene activation

Biotechnology - Impaired myenteric plexus NO production in colitis detected by bioimaging system

Biotechnology - Micromanipulation elucidates forces of actin-based propulsion

Bladder Cancer - Intravesical gemcitabine in superficial bladder cancer is well tolerated

Bladder Volume - Noninvasive pediatric bladder volume device launched

Blood Oxygenation - NIH grant to be used for development of adult brain oxygenation monitor

Bone Marrow Transplantation - Computerized system facilitates drug management

Brain Cancer - Encouraging post-market data reported on GliaSite treatment for brain tumors

Brain Tumors - Interstitial infusion of IL13-PE38QQR into rat brain stem may be future therapy

Brain Tumors - Study reviews molecular targeting for malignant gliomas

Breast Cancer - Breast reduction diminishes breast cancer in high-risk women

Breast Cancer - MR mammography: More sensitive detection, but higher false-positive rates

Breast Cancer - MammoSite boost radiation delivery shows promise in breast cancer study

Breast Cancer - Results from European study show strong RECAF expression by cancer cells

Breast Cancer - Technique helps determine axillary lymph node tumor status in some patients

Breast Cancer - Women with early breast cancer in Australia report needing more support

Burn Medicine - Suction dressings useful for immobilizing dermal substitute

Business & Finance - Safety syringe developer announces record sales

Business Update - AccuSoft Corp. acquires computing software product line

Business Update - Company announces first purchase order for Galileo in U.S.

Business Update - Diagnostics company changes name to Predicant

Business Update - PolyHeme maker added to Nasdaq Biotech Index

Business Update - Technology development company to conduct business under new name

Business Update - Transurgical, Inc., changes company name to reflect core business

Cancer - Altix system helps cancer center accelerate computational disease research

Cancer Metastasis - New methods improve hepatic colorectal metastases resectability

Cancer Metastasis - Tumor-ablative approaches can be used for colorectal liver metastases

Cancer Therapy - Company presents update on TNFerade at Digestive Disease Week

Cancer Therapy - Laryngeal paralysis due to TIVAD catheter tip migration reported

Cancer Therapy - New chemical adaptor unit releases a drug by enzymatic triggering

Cancer Therapy - Simple and sensitive method to measure trabectedin in plasma developed

Cardiac Resynchronization Therapy - New lead delivery tools launched for cardiac resynchronization therapy

Cardiology - Baroreceptor reflex function impaired in mice lacking alpha2A )-adrenoceptors

Cardiology - Causative organisms of infective endocarditis identified

Cardiology - Enzyme activation of the Ca-ATPase may occur through different mechanisms

Cardiology - Myocardial oxygen consumption rate is an index of postischemic recovery

Cardiology - Pacemaker lead endocarditis caused by Achromobacter xylosoxidans reported

Cardiology - Routine IVUS guidance not needed for coronary stent implantation

Cardiovascular Disease - RVOT pacing-defibrillation lead placement safe and effective

Cardiovascular Research - Cardiovascular research now involves proteomics

Cervical Cancer - DNA image cytometry used to diagnose cervical cancer

Cervical Cancer - Long-term outcomes of radiotherapy for cervical cancer reported

Chemotherapy - Mitomycin-C-loaded alginate carriers created for bladder cancer chemotherapy

Chiropractic Care - Technology takes tiny steps in hands-on chiropractic industry

Cholangiocarcinoma - Extended surgical resection improves prognosis of cholangiocarcinoma

Chronic Obstructive Pulmonary Disease - New noninvasive swab test for AAT deficiency offered

Clinical Trial - $1M in study extensions awarded for cardiac safety monitoring and services

Coagulation - Resonance thrombography useful for FDP screening

Collaborations - Deal signed for disease management services for Health Options

Collaborations - Diagnostics firms collaborate to help doctors differentiate allergy-like symptoms

Collaborations - IBM expands alliance to broaden life sciences initiatives

Collaborations - Novartis enters strategic antibody alliance

Collaborations - Partnership signed to offer new custom, standard genotyping products

Collaborations - Partnership to develop in vitro assays using hESC-derived hepatocytes

Collaborations - Pharmaceutical firms collaborate in trial of dermatology product

Collaborations - Service provider relationship deal signed with Fresenius Medical Care

Collaborations - Supply, license agreement signed for catheters

Colon Cancer - Different methods are needed to modifying attributions of colorectal cancer risk

Colonoscopy - Enrollment complete in phase II study of purgative product - INKP-102

Congestive Heart Failure - Research evaluates heart failure treatments for landmark study

Crohn Disease - Data show repeated treatment with Leukine is well tolerated

Crosslinking - Oxidative stress or UV irradiation elevates in situ TGase 2 activity

Cystoscopy - Flexible Cystoscope with Slide-On EndoSheath System launched

Dengue Fever - GRP 78 (BiP) identified as hepatic dengue virus serotype 2 receptor element

Diabetes Management - New Precision Xtra blood glucose test strip launched

Diagnostic Imaging - PET and conventional images of small-cell lung cancers are often discordant

Diagnostic Imaging - Tc-99m-HYNIC annexin-V scans identify primary tumors but miss lymph involvement

Diagnostics - Aminoglycoside array enables high-throughput analysis of RNA interactions

Diagnostics - Coagulation test identifies anti beta2 -glycoprotein I lupus anticoagulants

Diagnostics - Dermatofibrosarcoma protuberans must be distinguished from similar tumors

Diagnostics - Group A rotavirus quantitation by real-time RT-PCR correlates with severity

Diagnostics - Intraoperative liver ultrasound is important for hepatic tumor resection

Diagnostics - MedMira signs Canadian distributor to market Rapid HIV Test Kits

Diagnostics - Novel PCR test detects several fungal pathogens

Diagnostics - Novel immunoassay detects pathogenic E. coli in children

Diagnostics - Novel microarrays detect multple pathogens in serum

Diagnostics - Novel monoclonal antibodies facilitate flow cytometric Toxoplasma detection

Diagnostics - Pv30 antigen suitable for serodiagnosis of malaria in Korea

Diagnostics - Rigorous analysis is essential for classifying breast tissue specimens

Diagnostics - Sandwich dot-ELISA detects S. pneumoniae in CSF

Diagnostics - Semicarbazide and amine slides compared in peptide-protein microarray assay

Diagnostics - ViTALConnect medical diagnostic software tool introduced

Distribution Agreement - Ultrasound scanner company enters distribution relationship with AVS

Drug Delivery - FDA issues 510(k) clearance for eFlow electronic aerosol device

Drug Development - ReceptoPharm completes first step in production of RPI-78M.

Drug Resistance -  A. fumigatus variant has decreased susceptibility to multiple antifungals

Ebola Virus - Method for rapid diagnosis of Ebola hemorrhagic fever developed

Emergency Medicine - Triple-contrast CT depicts internal injury from gunshot and stab wounds

Environmental Health - Novel assay provides improved measure of haloacetic acids in drinking water

Enzymology - Anti-GM3 synthase antibody enables immunodetection in human tissue

Epidemiology - High prevalence of H. pylori contact in Argentina

Erectile Dysfunction - Penile prosthesis infection rates decrease with InhibiZone use, study shows

Expression Profiles - New multiplexed reagent introduced for protein, biomarker quantitation

Finance - Anesthetic delivery systems maker announces Q1 increases in domestic sales

Finance - Avitar reports second quarter financial results for fiscal 2004

Finance - Diagnostics company announces third quarter total revenue of $210,521

Finance - Diagnostics company reports improved Q2 and 6-month financial results

Finance - Dialysis services company declares three-for-two stock split

Finance - Digital imaging developer reports increase in revenues

Finance - EPT-focused company closes $10.90 million preferred stock financing

Finance - Electronic instrument makers reports record year-end sales and earnings

Finance - Imaging systems company reports 10% decrease in revenues

Finance - Ion-technology company announces 56% revenue growth for third quarter

Finance - Medical device company reports second quarter financial results

Finance - Medical device manufacturer reports 32% increase in sales

Finance - Medical product manufacturer reports first quarter financial results

Finance - Orthotics company reports net loss

Finance - Pharmaceutical company added to NASDAQ Biotech Index

Finance - Pharmaceutical firm raises $6.4M through sale of common stock

Finance - Stem-cell company awarded $1.3M grant from Israel

Food-Borne Illness - LC-MS/MS method to detect and measure acrylamide in coffee developed

Food-Borne Illness - Rapid method to measure enrofloxacin/ciprofloxacin in milk developed

Gastroenterolgy - Fibrin glue can effectively treat gastrocolonic fistula

Gene Mutation - Mutations in gene encoding filamin B disrupt vertebral segmentation

Genetic Marker - CCR5Delta32 polymorphism a risk factor for ischemic-type biliary lesions

Genetic Screening - A new assay quickly screens families at risk for medullary thyroid cancer

Genome Sequencing - $2.4M NIH grant to be used for picoliter-scale sequencing technology

Genomics - ACAT-1 transcripts predominate in liver and ACAT-2 predominate in the duodenum

Genomics - CRE-II site in SMN promoter positively regulates expression of SMN gene

Genomics - Release of iron from ferritin is an important part of the nicking mechanism

Genomics and Genetics - SrfA-dependent genes identified in Dictyostelium discoideum

Gynecological Cancer - Researchers review spirituality among gynecological cancer patients

Head Trauma - Nerve tissue protein S100 levels identify high-risk patients

Heart Attack - U.S. FDA issues clearance for RAMP Cardiac Marker Test

Heart Disease - Approval sought for human implantation of self-expanding stented heart valve

Heart Disorders - Collaboration to develop 3D image technology for electrophysiologists

Heart Failure - AbioCor implant patient removed from life support due to liver, kidney failure

Heart Failure - Implantable cardioverter defibrillator study results released

Hematological Cancer - Molecular WT1 assay useful for minimal residual disease monitoring

Hemodialysis - Convective-controlled double high flux hemodiafiltration shows promise

Hemodialysis - Tailored schedules may help retain residual renal function

Hepatitis - New preclinical results show prevention of liver injury by histamine

Hip Replacement - Cementless total hip arthroplasty feasible for elderly patients

Hip Replacement - Ultralok uncemented femoral prostheses effective for young patients

Hospital Error - Hospital fined for violations in heart transplant program

Imaging - Fischer Imaging to offer PACS and VIParchive technology

Imaging - Rotating camera puts fresh spin on coronary angiography

Imaging Technology - New mass spectrometry-based tissue imaging technology launched

Immune Suppressant - Everolimus safe and effective immunosuppressant in organ transplantation

Immunnology - Mouse bone marrow contains large numbers of functionally competent neutrophils

Immunology - Epitope-specific sorting method improves scFv characterization

Immunology - Grafted BM only variable associated with increased risk of CMV antigenemia

Immunology - Humanized agonistic anti-human 4-1BB mAb developed

Immunology - Interleukin concentrations vary in peritoneal fluid of women with endometriosis

Immunology - Regulatory role of Blimp-1 clarified

Immunology - Simulect use results in significant reduction in transplant rejection

Immunology - Standardized whole-blood leukocyte function assay validated

Immunology - T cells and macrophages main BAFF-expressing cells in salivary glands from pSS

Immunology - Various immune modulatory molecules induced in CD34+ hematopoietic cells

Implantable Devices - Breakthrough attributes of biothermal battery highlighted

Infection Control - $1.5B annual cost of surgical site infections can be reduced

Inflammatory Bowel Disease - Data presented on two gastrointestinal disease treatments

Information Tech - Clinical data sharing solution available for healthcare providers

Information Technology - Interactive obesity management program introduced

Irritable Bowel Syndrome - IBSTracker launched to study changing IBS marketplace

Ischemic Heart Disease - Coronary perfusion flow is larger in diastolic than systolic arrest in rats

Ischemic Heart Disease - Perioperative beta blocker use is inconsistent in heart disease patients

Ischemic Heart Disease - Urban air pollution may increase the risk of dying in Norway

Kidney Transplantation - Electronic monitoring provides optimal measure of immunosuppression adherence

Knee Replacement - Variables affecting post-TKA range of motion identified

Legal Issues - Inhaled nitric oxide gas and gas delivery devices lawsuit settled

Leukemia - Study looks at marrow stem cells and chemotherapy

Liver Cancer - Proteomics can be useful in researching hepatic diseases

Liver Cancer - Regional chemotherapy for liver tumors appears promising

Liver Cancer - Study reviews modern hepatic imaging

Liver Failure - New scintigraphy test could aid preoperative assessment of liver function

Liver Resection - Laparoscopic liver resection is safe and feasible

Liver Resection - Segmental approach to liver resection reduces intraoperative blood loss

Liver Transplantation - Numerical simulation model of hypothermic machine perfusion effective

Liver Transplants - Positive results reported in comparative Prograf trial

Liver Tumors - Benign liver tumors are found more frequently with abdominal imaging

Liver Tumors - Portal vein embolization can increase the safety of hepatic resection

Market Analysis - Attracting top clinical investigators requires careful planning

Market Analysis - Cardiovascular drugs represent $12.5B exposed to generics

Mass Spectrometry - New protein ID system helps researchers pinpoint more proteins

Medical - Mentor licenses patent covering method for treating urinary incontinence

Medical Devices - Electron holography facilitates study of MTJ microstructure

Melanoma Diagnosis - Proteomic evaluation yields possible uveal melanoma markers

Mergers and Acquisitions - Acquisition offer announced for Profile Therapeutics

Mergers and Acquisitions - Fisher announces expiration of waiting period under Hart-Scott-Rodino

Mergers and Acquisitions - Intermagnetics to acquire maker of RF coils

Mergers and Acquisitions - MediCor announces acquisition of breast implant company

Mergers and Acquisitions - Medical device firm acquired for $2 billion

Mergers and Acquisitions - Medical device supplier acquires medical manufacturing firm

Mergers and Acquisitions - Technology development company acquires Impedance Cardiography technology

Modeling - 3D models being used to determine gene development in heart

Neuroscience - Fluorescent labelling method facilitates 3-D imaging of cochlear tissues

Neuroscience - Microdialysis useful for monitoring cannabinoid influence on cAMP levels

Neuroscience - Novel microelectrode array can isolate individual neurons

Neuroscience - Portable system enables field recordings of primate single neuron activity

Neuroscience - Tissue transglutaminase likely plays important role in neuronal function

Nuclear Medicine - Lobectomy followed by radioiodine manages differential thyroid cancer

Obstetrics - Radioimmunoassay developed to measure 3,3'-T2S in maternal serum

Ophthalmology - Wearable low-vision device gives the sight-impaired a cyber helping hand

Organ Transplants - Registry data demonstrate superior long-term organ transplant outcomes

Orthopedic Surgery - Anterolateral mini-incision total hip replacement reviewed

Orthopedic Surgery - Posterior cruciate-retaining and posterior stabilized TKA compared

Orthopedic Surgery - Posterolateral minimal incision effective for total hip replacement

Orthopedics - Cementless femoral stem bone support compared with novel method

Orthopedics - Synthetic ligament prosthetic effective for recurrent THA dislocation

Orthopedics - Two acetabular cement pressurizers compared

Osteoporosis - New product launched for balloon kyphoplasty

Osteoporosis - Ospemifene effective in reducing bone turnover in postmenopausal women

Otorhinolaryngology - Novel technique improves outcome of laryngeal microsurgery

Ovarian Cancer - Inexperienced surgeons operate on most ovarian cancer patients in Maryland

Ovarian Tumors - Ovarian cystadenofibromas can have malignant features on CT and MRI

Ovarian Tumors - The accuracy of frozen section in diagnosis of ovarian masses is generally good

Pain Medicine - Cold compresses effective for pain relief after total hip replacement

Paralysis - 19-year-old undergoes rare procedure to reverse paralysis

Patents - Broad U.S. patent issued for computational drug design technology

Patents - Patent granted for germicidal device to prevent nosocomial infections

Patents - U.S. issued patent covers emollient-foam technology

Personnel - Allen Andersen named to board of supplement/personal care company

Personnel - CEO Ronald W. Dollens to retire after 32 years at Lilly, spin-off

Personnel - Cardiac diagnostics company announces election of new director

Personnel - Device company reports resignation of chief financial officer

Personnel - Device firm names Ronald L. Greene as VP, sales and marketing

Personnel - Diagnostic imaging services provider announces new chief executive officer

Personnel - Drug discovery supplier hires Charles Powell as VP of sales, marketing

Personnel - E-learning company names Hugh Rienhoff and Thanos Triant to board

Personnel - Gerard E. Puorro and Brian F. Sullivan join board of SonoPrepmaker

Personnel - Japanese life sciences firm names new CEO

Personnel - Jasjit Suri, PhD, becomes director of applied R&D for imaging company

Personnel - Litx company names John Marshall to scientific advisory board

Personnel - Mark Little elected to board; John Tarello retiring

Personnel - Michael Tognotti named director of sales at microarray company

Personnel - New chief executive officer to lead company in spinal implant product launches

Personnel - New president named at diagnostics firm, divestiture announced

Personnel - Patrick Balthrop named CEO of xMap company

Prenatal Testing - Novel technique brings prenatal testing from maternal blood closer to reality

Prognostics - p53 over-expression correlates with local treatment failure in oral carcinoma

Prostate Cancer - Antioxidant system activation is important for prostate cancer patients

Prostate Cancer - Chromosome 16q analysis reveals tumor suppressor gene candidates

Prostate Cancer - Hormonal therapy and radiotherapy improve survival for prostate cancer patients

Prostate Cancer - Quality of life declines in the year before death in men with prostate cancer

Prostate Cancer - Sexual disorders after radical prostatectomy involve the couple

Prostate Cancer - Study finds no connection between prostate cancer and atrazine exposure

Proteomics - CREB binds to multiple loci on chromosome 22

Proteomics - Clinical proteomics is revolutionizing disease detection

Proteomics - Protein secondary structure analyzed by vacuum-UV circular dichroism

Pulmonary - CE Mark approval granted new delivery system for surgical adhesive

Radiology - Dangers of MRI in patients with neurostimulators reviewed

Radiotherapy - Exclusive distribution agreement signed for OneDose surface dosimeter

Renal Disease - Phase I/II trial of E2F Decoy begins for prevention of AV graft failure

Restenosis - Implanted stents with c-myc suppressant engender arterial healing

Saphenous Vein Grafts - Rubicon Filter study in Europe yields positive 30-day follow-up results

Skin Cancer - Retinoid-modulated proteins identified in squamous carcinoma cells

Spine Surgery - Analysis shows non-fusion spine procedure revenues to total $27M in 2005

Staffing - Diagnostics company enters strategic agreement with Physicians On-Call

Stem Cell Research - Cxcr4 receptor may exert trophic influences on precursor cell proliferation

Stem Cell Research - Evidence found for fusion between cardiac and skeletal muscle cells

Stem Cell Research - Self-renewal capacity is a widespread property of neural crest precursor cells

Stem Cell Transplantation - Low-dose alemtuzumab reduces GVHD following myeloablative ASCT

Surgery - NIM-Spine System released; designed to reduce spinal-surgery risk

Surgical Technology - Anterior cervical plate system effective for cervical stabilization

Surgical Technology - NICE guidance has limited effect on procedure performances

Surgical Technology - Painless suction drain removal technique developed

Thyroid Tumors - Cyclin D1 overexpression is significant in thyroid tumors

Tissue Engineering - Crosslinking determines degradation rate and regeneration of acellular tissue

Tissue Engineering - Denatured collagen used as support for FGF-2 delivery system

Transfection - Expression system secretes TAT fusion proteins

Transfusion Medicine - Method developed to measure red blood cell survival following transfusion

Transgenics - Cx36-EGFP associated with AMPA-type glutamate receptor subunit GluR1

Transplantation Medicine - Recovery after HCT for leukemia or lymphoma can take 3-5 years

Ultrasound - Company launches new line of ultrasound probes for the replacement market

Uterine Fibroid Tumors - Effective radiation dose calculated for uterine artery embolization

Wound Care - Innovative "self healing" bandage to help diabetics

Wound Care - V.A.C. GranuFoam Heel Dressing earns APMA seal of approval

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