Drug Delivery
Chitosan membrane shows promise for transdermal dosing
Published in Medical Devices and Surgical Technology Week, June 27th, 2004
In a recent study from Thailand, the "release of a drug from a transdermal delivery system with a rate controlling chitosan membrane was analyzed in vitro and in vivo."
"Lidocaine hydrochloride, a local anesthetic, was used as the model drug. The in vitro permeability of various chitosan membranes for the drug was investigated using a Franz diffusion cell," explained W.W. Theinhan and coauthors at the Asian Institute of Technology in Bangkok.
"Drug release was slower through chitosan membranes with a higher degree of deacetylation (% DD) and with a larger...
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