Genomics & Genetics
Mixture modeling can improve quality of DNA microarray data
Published in Medical Devices and Surgical Technology Week, July 25th, 2004
The "DNA microarray is an important tool for the study of gene activities but the resultant data consisting of thousands of points are error-prone," researchers in Saudi Arabia explained. "A serious limitation in microarray analysis is the unreliability of the data generated from low signal intensities. Such data may produce erroneous gene expression ratios and cause unnecessary validation or post-analysis follow-up tasks."
To solve this problem, M.H. Asyali and colleagues at the King Faisal Specialist Hospital and Research Centre in Riyadh developed "an approach based on...
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