Acute Pancreatitis
Endothelial nitric oxide synthase is protective in mice
Published in Medical Devices and Surgical Technology Week, August 22nd, 2004
"The effect of inhibiting nitric oxide (NO) synthase (NOS) or enhancing NO on the course of acute pancreatitis (AP) is controversial," scientists in the United States explained, "in part because three NOS isoforms exist: neuronal (nNOS), endothelial (eNOS), and inducible (iNOS)."
In their study, M.J. Dimagno and colleagues at the University of Michigan "investigated whether inhibition or selective gene deletion of NOS isoforms modified the initiation phase of cerulein-induced AP in mice and explored whether this affected pancreatic microvascular blood flow...
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