Drug Development
Ultrafast analytical method developed for high-throughput parallel synthesis
Published in Medical Devices and Surgical Technology Week, November 28th, 2004
"High-throughput parallel synthesis of library compounds for early drug discovery requires high-throughput analytical methods to confirm synthesis, identify reaction products, and determine purity," scientists in Massachusetts explained.
In a study conducted by J.N. Kyranos and coauthors at Woburn-based ArQule, Inc., an "ultrafast 1.0-min HPLC/UV/ELSD/MS method was developed and compared to our standard 2.5- and 5.0-min methods in order to determine if the faster method was appropriate to evaluate compound synthesis and determine purity."
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