Toxicology
Simplified in vitro genotoxicity screening tests show promise
Published in Medical Devices and Surgical Technology Week, February 6th, 2005
"Aristolochic acid (AA), the active compound found in Aristolochia extracts, has been used as a traditional medicine," scientists in the United States explained. "However, products containing AA were withdrawn from the market in the early 1980s because AA was found to be a potent carcinogen."
"Some genotoxicity studies of AA were conducted after the carcinogenicity of AA was reported," noted H. Zhang and colleagues at Covance Laboratories Inc., who conducted a study "to check the ability of simplified, screening tests for genotoxicity to...
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