Published in Medical Devices and Surgical Technology Week, March 20th, 2005
"Alpha-catenin is a crucial part of the Wnt and E-cadherin signaling pathways, which are involved in tumorigenesis," pathologists in Canada explained. "Dysregulation of these pathways allow beta-catenin to accumulate and translocate to the nucleus, where it may activate oncogenes."
"Such nuclear accumulation can be detected by immunohistochemistry, which may be useful in diagnosis," noted T.L. Ng and colleagues at the University of British Columbia. "Although the role of beta-catenin has been established in various types of carcinomas, relatively little is known...
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