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Prion Diseases

Novel immunoassay accurately detects abnormal prion protein

Published in Medical Devices and Surgical Technology Week, March 20th, 2005

A novel immunoassay enables simple and accurate detection of the abnormal prion protein (PrPSc).

"Transmissible spongiform encephalopathies (TSEs), also termed prion diseases, are fatal neurodegenerative conditions that affect both humans and animals," scientists in the United States explained. "The transmissibility and fatal nature of TSEs necessitate their rapid and accurate diagnosis."

"Laser-induced fluorescence (LIF) spectrofluorometry is useful for obtaining measurements on fluorescence-labeled targets with a high degree of sensitivity," noted J.I. Kim and colleagues at the New York State Institute for Basic Research in Developmental...

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