HIV/AIDS Pathogenesis
HIV-1 Vpr inhibits maturation and activation of macrophages and dendritic cells
Published in Medical Devices and Surgical Technology Week, April 17th, 2005
"Human immunodeficiency virus-1 (HIV-1) Vpr encodes a 14 kDa protein that has been implicated in viral pathogenesis through in vitro modulation of several host cell functions. Vpr modulates cellular proliferation, cell differentiation, apoptosis and host cell transcription in a manner that involves the glucocorticoid pathway.
"To better understand the role of HIV-1 Vpr in host gene expression, similar to9600 cellular RNA transcripts were assessed for their modulation in primary APC after treatment with a bioactive recombinant Vpr (rVpr) by DNA micro-array," wrote...
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