Diagnostics
Leukocyte HLA-B*420502 allele identified by HLA typing and subsequent sequencing
Published in Medical Devices and Surgical Technology Week, May 22nd, 2005
According to recent research from Czech Republic, "A novel human leukocyte antigen-B (HLA-B) allele, B*420502, was identified in a patient with leukemia (Caucasoid, Czech ancestry) and his mother during intrafamily search for the hematopoietic stem cell donor.
"The novel allele was initially detected by HLA typing at low resolution using both sequence specific primers and sequence specific oligonucleotides techniques that resulted in unique reaction patterns. The alleles of the HLA-B locus were separated by the haplotype-specific extraction technique."
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