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Cardiac Allografts

Rejection of B6.H-2bm12 heart allografts is inhibited by regulatory cells

Published in Medical Devices and Surgical Technology Week, May 22nd, 2005

Alloreactive T cell responses and acute rejection of single class II MHC-disparate heart allografts are under strict regulation by CD4+CD25+ T cells.

According to published research from the United States, "Skin but not vascularized cardiac allografts from B6.H-2bm12 mice are acutely rejected by C57BL/6 recipients in response to the single class II MHC disparity. The underlying mechanisms preventing acute rejection of B6.H-2bm12 heart allografts by C57BL/6 recipients were investigated."

S. Schenk and colleagues of the Cleveland Clinic Foundation reported, "B6.H-2bm12 heart allografts induced low...

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