Fetal Hematopoiesis
Placenta is a niche for hematopoietic stem cells
Published in Medical Devices and Surgical Technology Week, May 29th, 2005
"The hematopoietic system develops during embryogenesis at temporally and anatomically restricted sites. The anatomical origin of definitive HSCs is not fully resolved, and little is known about how the different fetal hematopoietic microenvironments direct HSC development.
"Here, we show that the mouse placenta functions as a hematopoietic organ that harbors a large pool of pluripotent HSCs during midge-station," researchers in the United States report.
"The onset of HSC activity in the placenta parallels that of the AGM (aorta-gonad-mesonephros) region starting at...
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