Published in Medical Devices and Surgical Technology Week, June 26th, 2005
According to a study from England, "The beta-catenin protein is at the core of the canonical Wnt signaling pathway. Wnt stimulation leads to beta-catenin accumulation, nuclear translocation and interaction with T-cell factor/lymphoid enhancer factor (TCF/LEF) transcription factors to regulate genes important for embryonic development and proliferation.
"Wnt/beta-catenin can promote stem cell self-renewal and is dysregulated in colon carcinoma. We have examined the role of the Wnt pathway in the development of acute myeloid leukemia (AML) and find that the...
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