Neuroscience
HPLC conditions strongly influence GABA detection by microdialysis
Published in Medical Devices and Surgical Technology Week, October 16th, 2005
"In microdialysis studies, neither exocytotic release of gamma-aminobutyric acid (GABA), nor the presence of GABA type B (GABAB ) autoreceptors, have been clearly established," according to scientists in the Netherlands, who "investigated whether the chromatographic separation of GABA may have contributed to discrepancies in the literature
"After extending the profile of the HPLC chromatogram to a retention time of 60 min, it was observed that various unknown compounds of biological origin co-eluted near the GABA peak," noted K....
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