Stem Cell Transplantation
Integrin and extracellular matrix interactions regulate hepatocyte engraftment
Published in Medical Devices and Surgical Technology Week, January 15th, 2006
"Recognition and circumvention of the hepatic endothelial barrier is critical in the engraftment of transplanted cells. We examined whether interactions between integrin and extracellular matrix component receptors could be manipulated for improving transplanted cell engraftment and liver repopulation," scientists in the United States report.
According to the authors, "Fischer 344 rat hepatocytes were transplanted into syngeneic dipeptidyl peptidase IV-deficient rats. Coating of cells or of liver sinusoids with natural collagen, natural laminin, or an...
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