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Cancer Research
High leptin receptor mRNA expression and leptin levels in breast cancer predicts poor outcome
April 11th, 2006
High expression of leptin receptor mRNA in breast cancer tissue predicts poor prognosis for patients with high, but not low, serum leptin levels. "The association of mRNA expression levels of leptin receptors (long isoform: Lep-R(L) and short isoform: Lep-R(S)) in breast cancer tissue with patient prognosis was studied with special reference to the serum leptin level or the leptin mRNA level in tumor tissue. Lep-R(L), Lep-R(S) and leptin mRNA levels in breast cancer tissue (n=91) were determined with a real-time PCR assay, and serum leptin levels in breast cancer patients (n=67) with an enzyme-linked immunosorbent assay," researchers in Japan report. ...
Source: Medical Devices & Surgical Technology Week (2006-04-11)
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