Molecular Biology
Research from Engelhardt Institute of Molecular Biology, Biology Department provides new data on molecular biology
Published in Medical Devices and Surgical Technology Week, May 6th, 2007
Data detailed in "Analysis of T-cell receptor-gamma gene rearrangements using oligonucleotide microchip: a novel approach for the determination of T-cell clonality" have been presented. "T-cell clonality estimation is important for the differential diagnosis between malignant and nonmalignant T-cell proliferation. Routinely used methods include polymerase chain reaction (PCR) analysis of T-cell receptor-gamma (TCR-gamma) gene rearrangements followed by Genescan analysis, polyacrylamide gel electrophoresis, or heteroduplex analysis to visualize amplification products," investigators in Russia report.
"Here, we present a new method for the analysis after PCR of TCR-gamma...
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