Capillary Electrophoresis

Reports from E.J. Ashton and co-researchers add new data to research in capillary electrophoresis

Published in Medical Devices and Surgical Technology Week, March 23rd, 2008

"We have developed a technique to screen for gross deletions/duplications and point mutations using one streamlined approach. Fluorescent multiplex quantitative PCR is used to determine the copy number of each exon, followed by conformation sensitive capillary electrophoresis (CSCE) of the same PCR products on a multi-capillary genetic analyser," investigators in London, the United Kingdom report.

"We have developed this technique to screen all 79 exons of one of the largest human genes currently known ( dystrophin) using 12 multiplex PCR assays. A blind trial of 50 male and 50 female samples, in which 84 mutations had previously been found and characterized by other...

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Source: Medical Devices and Surgical Technology Week (2008-03-23)

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