Chromatography
Researchers from Amgen, Inc., Department of Pharmaceutics publish new studies and findings in the area of chromatography
Published in Medical Devices and Surgical Technology Week, March 23rd, 2008
A new study, 'Reversed-phase liquid chromatography-mass spectrometry of site-specific chemical modifications in intact immunoglobulin molecules and their fragments,' is now available. According to recent research from the United States, "The employment of a diphenyl column for the separation of intact monoclonal antibodies (mAbs) and their fragments by reversed-phase HPLC is discussed as a novel approach for the characterization of chemical modifications in a site-specific manner. Chromatographic separation of the intact mAb07 on the diphenyl support resulted in the separation of the cysteinylated from the non-cysteinylated mAb."
"A detected mass increase of 119 Da by...
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