Life Sciences
Investigators at Case Western Reserve University, Department of Biochemistry release new data on life sciences
Published in Medical Devices and Surgical Technology Week, June 1st, 2008
Fresh data on life sciences are presented in the report 'Oxidative modification of cytochrome c by singlet oxygen.' According to recent research from the United States, "Singlet oxygen ((1)O(2)) is a reactive oxygen species that may be generated in biological systems. Photodynamic therapy generates (1)O(2) by photoexcitation of sensitizers resulting in intracellular oxidative stress and induction of apoptosis. (1)O(2) oxidizes amino acid side chains of proteins and inactivates enzymes when generated in vitro."
"Among proteogenic amino acids, His, Tyr, Met, Cys, and Trp are known to be oxidized by (1)O(2) at physiological pH. However, there is a lack of direct evidence...
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