Surgical Technology

New lung cancer research from National Cancer Institute described

Published in Medical Devices and Surgical Technology Week, July 27th, 2008

According to recent research from the United States, "Hemiasterlin (Hem) and dolastatin (Dol) are marine natural products which are cytotoxic for cancer cells. Hem, a tripeptide, and Dol, a hexapeptide, were conjugated with linkers (L) to the universal BB agonist DPhe-Gln-Trp-Ala-Val-beta Ala-His-Phe-Nle-NH2(BA1) and the effects of the Hem-BB and Dol-BB conjugates investigated on NCI-H1299 lung cancer cells."

"Hem-LA-BA1 and Hem-LB-BA1 inhibited specific (I-125-Tyr(4)) BB binding to NCI-H1299 cells, which have 13132 receptors (R), with IC50 values of 15 and 25 nM, respectively. Addition of Hem-LA-BA1 and Hem-LB-BA1 to Fura-2 AM loaded cells containing BB2R, caused...

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Source: Medical Devices and Surgical Technology Week (2008-07-27)

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