Acid Reflux Disease

Researchers from Erasmus University describe findings in acid reflux disease

Published in Medical Devices and Surgical Technology Week, July 27th, 2008

" Chronic oesophageal inflammation and related oxidative stress are important in the pathogenesis of erosive oesophagitis (EO) and its malignant progression. To study the effect of proton pump inhibitors (PPIs) on oesophageal cellular immune response and oxidative damage in EO patients," scientists writing in the journal Alimentary Pharmacology & Therapeutics report.

" Forty gastro-oesophageal reflux disease (GERD) patients [non-erosive reflux disease (NERD): 15, EO: 25] were included, after 7 days off antisuppressive drugs. EO patients were randomized to 20-mg rabeprazole once daily for either 4 or 8 weeks with baseline and follow-up endoscopy with distal...

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Source: Medical Devices and Surgical Technology Week (2008-07-27)

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