HIV/AIDS

New research on HIV/AIDS from V. Micheli and co-authors summarized

Published in Medical Devices and Surgical Technology Week, August 3rd, 2008

According to recent research from Milan, Italy, "Liver disease may alter the pharmacokinetics of antiretrovirals and produce changes in plasma protein binding. The aim was to evaluate the pharmacokinetics of total and unbound lopinavir (LPV) in HIV-infected patients with and without hepatitis C virus (HCV) coinfection."

"Fifty-six HIV+ patients receiving lopinavir/ritonavir (LPV/r) (group I = 24 controls-, II = 23 HIV/HCV-coinfected; III = 9 cirrhotic HIV/HCV-coinfected) were included. Total (n = 56) and unbound (n = 36) LPV pharmacokinetic parameters were determined at steady-state using validated high-performance liquid chromatography with ultraviolet detection and...

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Source: Medical Devices and Surgical Technology Week (2008-08-03)

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