DNA Research

Data on DNA research described by researchers at Waseda University

Published in Medical Devices and Surgical Technology Week, November 23rd, 2008

"The effects of surface charge density on DNA hybridization have been investigated on a mixture of hydrogen-, oxygen-, and amine-terminated diamond surfaces. A difference in the hybridization efficiencies of complementary and mismatched DNA was clearly observed by fluorescence and potentiometric observations at a particular coverage of oxygen," researchers in Okubo, Japan report.

"In the fluorescence observation, singly mismatched DNA was detected with high contrast after appropriate hybridization on the surface with 10-20% oxygen coverage. The amount of oxygen in the form of C-O- (deprotonated C-OH) producing the surface negative-charge density was estimated by X-ray...

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Source: Medical Devices and Surgical Technology Week (2008-11-23)

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